The Hottest New Product in 2022: Non-Cross-Linked Sis Ldental Collagen Membrane

• Customization: Available
• Usage: Maxillofacial Prosthesis Materials, Planting Material, Filling Material
• Usage Times: Disposable
• Model NO.: SIS-ORP-2L-2*2CM
• Material: Porcine Small Intestinal Sub Mucosa
• Applicable Departments: Oral Surgery
• Nature: Alternative Recycled Materials
• Certification: FDA
• Sterilization: Eo Sterilezation
• Application: Dental Prosthetics, Oral Tissue Membrane
• Absorbable: Yes
• Keywords: Dental Implants, Oral Cavity Repai Graft, Oral Tis
• Transport Package: Envelope Packaging
• Specification: SIS-ORP-2L-2*3CM
• Trademark: biosis
• Origin: China
• Production Capacity: 1000

Product Description

Compared with Bio-Gide collagen membrane, it has a long-lasting isolation effect, which can last up to 8 weeks;
It is rich in bioactive substances, promoting cell attachment and tissue regeneration;
It can quickly guide blood vessels to grow into the body after implantation; it has a similar effect of guiding bone regeneration;It has excellent infection tolerance and immune safety performance.
Compared with other SIS membranes
The mild decellularization process is used to retain bioactive substances and promote cell attachment and tissue regeneration. The products are diverse, including oral repair membranes (thinner, suitable for oral soft tissue repair) and absorbable biomembranes (thicker, suitable for oral bone tissue defect repair)
Compared to inert tissue source materials such as bovine leather
SIS has good softness and hydrophilicity, which can better fit the defect area and facilitate operation;
It is rich in bioactive substances and can effectively guide osteogenic differentiation, thereby promoting bone regeneration;It has better guided bone regeneration effect,Excellent infection tolerance and immune safety performance
Key Features
1. Exquisitely Soft Membrane: Engineered for Enhanced Patient Comfort
2. Superior Hydrophilicity: Ready-to-Use Without Pre-Hydration
3. Versatile Sizing: Available from 1x1cm to 8x8cm, Ideal for Maxillofacial Surgery
4. Exceptional Regenerative Power: Retains Over 43% ***, Leading the Market
5. Fully Absorbable: 100% Absorption Within 3-4 Months

6. Dual Protection: Isolation and Protection with Anti-inflammatory and Anti-infection Properties
7. Advanced Regeneration: Facilitates Guided Bone and Tissue Regeneration (GBR & GTR)
8. Rich in Active Factors: Promotes Efficient Tissue Regeneration and Repair
9. Natural Composition: Includes Collagen Types I, III, IV, and VI, Glycosaminoglycans, Glycoproteins, Proteoglycans, and Growth Factors
10. Superior Substitute: Replaces Inert Tissue-Derived Biomaterials Like Dermal Matrix, Collagen, or Pericardium Products Without Cross-Linking
agents, No DNA Residue, Ensuring Safety & Effectiveness
Clinical Applications
Our bioregenerative membranes: Designed for a variety of tissue defect treatments to promote effective tissue regeneration
In dentistry: Ideal for bone replacement implants in a variety of treatments, preventing soft tissue ingrowth and ensuring successful regenerative outcomes
* Extraction Socket Management:
Expertly Handles Minor Bone Defects: Ideal for Extraction Socket Filling, Immediate, Early, Conventional, and Delayed Implantation, as well as Dental Bridge Bone Grafting
and ensures optimal results
* Maxillary Sinus Floor Lifting
* Periodontal Regeneration
* Vertical and Horizontal Bone Augmentation
* Oral-Maxillofacial Cyst Filling
In wet state, the support performance of SIS material is between ADM and Bio-Gide, and it has soft and conformable properties, and the membrane is easy to unfold.

The dense layer of fibers is dense, which can effectively prevent epithelial cells and connective tissue from growing into the bone defect area. The isolation effect can last up to 8 weeks.
The loose surface has loose fibers and large pores, which are conducive to cell attachment. Implantation in the body quickly induces angiogenesis, guides bone regeneration, and forms woven bone in the defect area within 6 weeks.

SIS contains host defense peptides. The antimicrobial peptides P1 (cecropin P1), PR-39, NK-lysin and other small peptide molecules generated after the degradation of SIS materials are the endogenous infection inhibition mechanism of SIS materials, which are more suitable for use in the oral environment.
(A) In vitro degradation rate curve of this product and Bio-Gide membrane (B) In vitro degradation rate curve of SIS membrane and Bio-Gide membrane in the literature
(A) Pictures of the degradation of this product and Bio-Gide membrane after in vivo implantation, (B) HE staining of SIS membrane and Bio-Gide subcutaneously implanted at 4, 8, and 12 weeks in the literature